I-Digoxin iyisidakamizwa esetshenziswa kabanzi ekwelapheni izifo zenhliziyo, kaningi ngesimo samathebulethi. Ubhekiselwa eqenjini lezemithi ye-glycosides yenhliziyo - imithi yamagciwane, ene-cardiotonic kanye ne-antiarrhythm effect.
Ukwakhiwa kwamakhemikhali kanye nomphumela wokwelashwa kwamathebulethi i-Digoxin
Isithako esisebenzayo seDakamizwa i-Digoxidine yinto efana neyegazi digoxidine, engabelwe amaqabunga esitshalo, i-digitalis woolly. Ezinye izingxenye zefomu lamathebulethi yilezi zidakamizwa:
- i-silicon dioxide colloidal;
- i-gelatin;
- i-magnesium stearate;
- i-talc;
- isitashi kusuka endle;
- i-lactose monohydrate.
Uma kuthathwa ngomlomo, isidakamizwa sithinteka emaphethelweni emathunjini futhi sithola umphumela wayo cishe amahora angu-2-3 ngemuva kokungenisa. Umthelela wezokwelapha uhlala okungenani amahora angu-6. Isixazululo sithengiswa ikakhulukazi ngomchamo.
Ngaphansi kwethonya lemithi esebenzayo yalesi sidakamizwa, imiphumela elandelayo ibonakala:
- ukwanda ngamandla we-myocardial muscle contractions (umphumela omuhle we-inotropic);
- ukwanda komthamo wokudabuka kwegazi;
- ukwehla kumvamisa wezinhlangothi zezinsizwa zenhliziyo;
- ukunciphisa kwevolumu ye-systolic neyokuphela kwe-diastolic yenhliziyo;
- kunciphise ukufunwa kwe-oxygen kwe-myocardium;
- isenzo sokungavumelani (ngokunciphisa izinga lemisindo ngokusebenzisa i-node atrioventricular kanye nokwandisa isikhathi esiphuthumayo se-refractivity);
- i-vasodilator effect (ngokubambisana ngemuva kwesihluku senhliziyo );
- umthelela omuhle wesimiso;
- ukunciphisa ukuphefumula;
- ukwehla ku-edema, njll.
Izimpawu zokusetshenziswa kwesidakamizwa i-Digoxin
Izinkomba eziyinhloko zokusetshenziswa kwemithi Digoxin ziyizifo ezinjalo:
- ukuhluleka kwenhliziyo okungapheli kwama-II, III kanye no-IV amakilasi asebenzayo (njengengxenye yezokwelapha eziyinkimbinkimbi);
- uhlobo lwe-tachycardic lwe-fibrillation ye-atrial;
- ukuphefumula kwe-atrial paroxysmal;
- i-paroxysmal tachycardia engaphezulu.
Ukuhambisana nomthamo nokusebenzisa amaphilisi i-Digoxin
Ngokuqondene nazo zonke izidakamizwa eziseqembu lama-glycosides enhliziyo, umthamo we-Digoxin ukhethwe ngokucophelela ngudokotela oya khona, ecabangela izici zomuntu ngamunye wesiguli, ubunzima kanye nezinqubo ze-pathological, kanye nemigomo ye-electrocardiogram ye-cardiac.
Isibonelo, omunye wemigomo yokuthatha lesi sidakamizwa ifomu lethebhulethi ihilela ukuqokwa kukaGigoxin ngenani lika-0.25 mg izikhathi 4-5 ngosuku lokuqala lokuphathwa, futhi ezinsukwini ezilandelayo - 0.25 mg ezintathu kuya kanye ngosuku. Kulokhu, ukwamukela kufanele kwenziwe ngaphansi kokuqondiswa odokotela.
Ngemva komphumela wokwelashwa okudingekayo (ngokuvamile emva kwezinsuku ezingu-7 kuya kwezingu-10), umthamo wehlisiwe, ukulinganisa izidakamizwa zezidakamizwa kunqunyelwe ukusetshenziswa kwesikhathi eside. Ukuqokwa kwe-injection intravenous, njengoba umthetho, kuyadingeka uma kwenzeka ukwehluleka okukhulu kwegazi.
Imiphumela emibi ye-Digoxin:
- isicasuli;
- ukuhlanza;
- izinkinga zesitoreji;
- ukungabi nesifiso sokudla;
- ikhanda;
- isiyezi;
- ukuphazamiseka kokulala;
- ukuhluleka kwenhliziyo;
- ukuphuma kwegazi;
- itching;
- i-urticaria;
- ubuthakathaka jikelele;
- ukukhathala, njll
Ukungafani kokusetshenziswa kwe-Digoxin:
- ukuxwala nge-glycosides yenhliziyo;
- i-infarction eyingozi ye-myocardial;
- angina engazinzile ;
- I-Wolff-Parkinson-White syndrome;
- i-atrioventricular block;
- i-bradycardia enezibonakaliso ezibalulekile zemitholampilo;
- isifo senhliziyo esiyingozi;
- mitral stenosis nabanye.