Zonke izifo zesimiso sokugaya umzimba zihlotshaniswa nokuwohloka kwemishini yokusebenza nokukhishwa kwamathumbu amancane namakhulu, isisu nesisu. Le nkinga ibaluleke ngokukhethekile ekusebenzeni i-dyspepsia, i-dyskinesia ye-biliary nesifo se-reflux se-gastroesophageal. Ukwelashwa kwezifo ezinjalo ze-pathologies prokinetics zesizukulwane esisha kusetshenziswa - imithi evumela ukubuyisela ukusebenza okujwayelekile komuthi wamathumbu.
Prokinetics yanamuhla
Izakhiwo zeprokine zinezinhlobo zamakhemikhali eziningi, kuhlanganise nama-peptide ama-hormonal, ama-antibiotic a-macrolide-nohlobo lwe-opiate receptor. Kodwa kufanele sikhethe izidakamizwa ezenza imisebenzi elandelayo:
- ukwanda kwezwi le-sphincter elingaphansi kwe-esophageal;
- ukuphuculwa kokuhlanzwa kwe-esophageal;
- ukwanda komzimba wesisu;
- ukwehla kwenombolo ye-refluxes eyinkimbinkimbi kanye nesikhathi sokuxhumana kwe-mucosa ye-esophagus nezindaba zesisu;
- ukuqedwa kokuphuma okulibalekile kokuqukethwe kwesisu.
Namuhla, iqembu le-prokinetic lisetshenziselwa kakhulu, elichaphazela ukusebenza kwepheshana eliphezulu lesisu:
- i-itopride;
- i-metoclopramide;
- i-cisapride;
- domperidone.
Ake siwahlole ngokuningiliziwe.
Yikuphi ama-prokinetics angcono?
Itopride noma itopride hydrochloride yinto esebenzayo eyenza imiphumela emibili ngesikhathi esisodwa:
- ukwanda ekukhululweni kwama-molecular acetylcholine;
- ukukhuthazwa kwama-receptor muscarinic.
Izinzuzo ze-tiotropium ingumphumela omuhle ku-sphincter ye-esophageal, okwandisa ithoni ye-gallbladder kanye nomsebenzi wemisipha yamathumbu aminyene namancane. Ngakho-ke, izidakamizwa ezisekelwe kulesi sici esinikeziwe zingasetshenziswa ku-syndrome of irritation of the intestine ngokuhlanganiswa nokusebenza komzimba we-dyspepsia nokuqothulwa. Ngaphezu kwalokho, lesi sakhi sithuthukisa kakhulu ukunyakaza kwezivumelwano esiyingxenyeni yesisu, kukhuthaza ukunyamalala kwe-reflux ye-duodenogastric futhi kuvelise umphumela we-antiemétique.
Iprokinetics yesizukulwane esisha ngesisekelo se-ticopride:
- I-Ganaton;
- Itomed;
- I-Primer.
Zitholakala amaphilisi anezilinganiso ezifanayo ezithinta izithako zika-50 mg.
Umzila olandelayo wezidakamizwa u-metoclopramide. Leli qembu lezidakamizwa linemisebenzi ephezulu kakhulu ngenxa yezinqubo eziningana zokwenza amaphrojekthi, okunye okukwenziwa ngokuqondile kwezingqinamba zezingxube ezibushelelezi ze-tube digestive.
Kumele uqaphele ukuthi i-metoclopramides inqunyelwe kuphela lapho kwenzeka khona ikhambi elifushane lokulashwa kanye nesidingo sokufeza imiphumela ngokushesha. Lokhu kungenxa yokuba khona kwenani elikhulu lemiphumela emibi. Phakathi kwalabo abamele leli qembu esiyiqaphele:
- I-Raglan;
- Ukhalile.
I-Cisapride ibhekwa njengenye yemithi ephumelela kakhulu yohlobo oluchazwe. Isici sabo esikhethekile yi-activation yohlu olusha lwe-receotors ye-serotonin, ekhona endaweni ye-plexuses ye-neurons yesisu, isisu nomathumbu. Imithi yeli qembu ihlanganisa:
- Ukulungiswa;
- Kuqedile.
Ngesikhathi esifanayo, i-cisaprial prokinetics ezibhebheni iqhubekisela phambili ukuthuthukiswa kwemiphumela emibi emithonjeni ye-cardiovascular
Isidakamizwa esithandwa kakhulu futhi esingabizi kakhulu seqembu elichazwe yi-domperidone (i-Motilium). Ukuphumelela kokusebenza kokwelapha akudluli ukusebenza kwe-metoclopramide, kodwa akubanga imiphumela emibi. Ukuhlukunyezwa kuphela kwe-Motilium kubonakala ngezifundo zesikhathi eside zokwamukelwa ngendlela yokwandisa izinga le-hormone prolactin.
I-prokinetic engcono kakhulu
Ukucabangela zonke izakhiwo ezichazwe ngenhla yemithi yeprokinetic yanamuhla, kungaphetha ngokuthi izidakamizwa ezithandwa kakhulu yizikhwama ezisekelwe ku-itopride.