Warfarin analogues

I-Warfarin yisidakamizwa esidala kunazo zonke esivela eqenjini lama- anticoagulants , ngokudlula ngokweqile kube yingozi futhi kudingeke ukuba kuqashwe njalo izinkomba zegazi. Kuze kube manje, kunezifanekiselo zesimanjemanje ze-Warfarin ezinemiphumela emibi kakhulu, phakathi kwazo okuyinto ezithakazelisa kakhulu yizo ezingathathwa ngaphandle kokuqapha okujwayelekile kwe-INR (isibonakaliso esichaza ukuhlanganiswa kwegazi).

I-Warfarin yanamuhla yama-Analogues

I-Warfarex

Amathebulethi aqukethe i-1.3 noma i-5 mg yesithako esisebenzayo (i-warfarin ye-sodium). Kusetshenziswe ku:

• i-thromboembolism yamaphaphu;
• i-thrombosis ejulile ye-vein;
• ukuhlasela kwenhliziyo;
• ama-valve of valves yenhliziyo.

Marewan

Amathebulethi aqukethe 3 mg we-warfarin ye-sodium. Kusetshenziswe ku:

• i-thrombosis;
• i-infarction kanye nokuvimbela izinkinga emva kokuhlaselwa kwenhliziyo;
• ezinye izifo zenhliziyo, kuhlanganise ne-valve prosthetics;
• ukwelashwa nokuvimbela ukushaywa kanye nokuhlaselwa kwe-ischemic.

Zombili izidakamizwa, eqinisweni, ziyi-Warfarin efanayo futhi zihluke kuphela kokuqukethwe kwezinto ezizayo. Ukuqapha i-INR nezinye izinyathelo zokuqapha lapho kusetshenziswa kuyimpoqo.

Yini enye engayenza esikhundleni seWarfarin?

Lapha sizocabangela amalungiselelo nezinye izinto ezisebenzayo kanye nohlobo lwezenzo eziyi-anticoagulants, ngakho-ke zingasetshenziswa esikhundleni se-Warfarin.

Pradaxa

Isidakamizwa singumuthi oqondile we-thrombin futhi, ngokuyibopha, kuvimbela ukwakheka kwe-thrombi. Isidakamizwa sisetshenziswa:

• ekwelapheni nasekuvimbelweni kwe-thrombosis yamalungu;
• ekuvimbeleni imivimbo , thromboembolism yesistimu;
• ukunciphisa ingozi yezinkinga ekufubeni kwe-atrial.

I-Xarelto (i-rivaroxaban)

I-inhibitor eqondile ye-factor Xa (i-coagulation factor, okuyi-activator ye-prothrombin). Lesi sidakamizwa sivimbela ukwakheka kwama-molecule amasha we-thrombin futhi akuthinti labo asevele bekhona egazini. Isetshenziselwa ukuvimbela:

• i-thromboembolism ngemuva kokusebenza kwamathambo emilenzeni engaphansi;
• imivimbo kanye ne-systemic thromboembolism kwiziguli ezine-fibrillation e-atrial.

Yikuphi okungcono - i-Pradaksa, i-Xarelto noma i-Warfarin?

Inzuzo ecacile kaPradax, njengo-Xarelto, ukuthi lezi zidakamizwa azidingi ukulawulwa kwe-INR futhi, uma kuthathwa, ingozi encane yemiphumela emibi. Nokho, lezi zidakamizwa Zisetshenziselwa kuphela izinhlobo ze-non-valvular zesifo senhliziyo. Lokhu kungukuthi, uma kuneziphazamisi zokufakelwa noma umonakalo we-rheumatic ezinqabeni zenhliziyo, azibekiwe, ngokungafani neWarfarin.

Uma ukhetha phakathi kwe-Xarelto ne-Pradaksa, kufanelekile ukucabangela ukuthi i-Xarelto ithathwa kanye kuphela ngosuku, futhi i-Pradaksa ingadinga amasu ambalwa. Ngaphezu kwalokho, kukholelwa ukuthi i-Xarelto ayiyona into ephazamisayo kakhulu ethinta ipheshana lomzimba.

Njengoba zonke lezi zidakamizwa zithinta izinkomba ezibalulekile, kungukuthi udokotela ukucacisa ukuthi impi ye-warfarin izothathelwa esikhundleni sini nokuthi ngabe izilinganiso zayo ziyamukeleka yini.