Ingqikithi ye-immunoglobulin E (Ig E) iyisici esibalulekile sempendulo ye-anthelmintic kanye nesibonakaliso sokuphendula okwenziwe okwenzeka ngokushesha. Isivivinyo se-Ig E sisetshenziselwa ukuxilonga izifo ezihlukahlukene ze-allergies kanye ne-helminthiase (i-atopic dermatitis, i-urticaria, i-asthma ye-bronchial inopic).
Iyini i-immunoglobulin ejwayelekile?
Ingqikithi ye-immunoglobulin E ivikela izimbungulu ezihlukahlukene zangaphandle zomzimba ngokusebenza kwendawo yamaseli we-effector nama-plasma izici ngokunciphisa ukuphendula okuvuvukala. Ngokungafani nezinye izinhlobo ze-immunoglobulins (D, M, A, G), kubangela ukuqwashisa kwezicubu ezilwaneni, okuqinisekisa ukuthuthukiswa okusheshayo kokusabela okwenziwe. Ig E ikhiqizwa endaweni yangakini. Lokhu kwenzeka ngokuyinhloko ungqimba oluncane lwezakhi ezinhlobonhlobo, ezihlala zixhumana nemvelo yangaphandle. Kungaba:
- isikhumba;
- amathani;
- i-adenoids;
- Ipheshana lokuphefumula;
- ipheshana lamathunjini.
Uma i-allergen ingena emzimbeni womuntu, ihambisana ne-immunoglobulin E. evamile Le nqubo ihambisana nokukhululwa kwamaseli e-histamine nezinto ezihlukahlukene ezisebenzayo embranini lapho i-Ig E ihleli khona. Ukungena kwabo esikhaleni se-intercellular kuholela ekuthuthukiseni okusheshayo kwesenzo sokuvuvukala esikuyo. Ibonakala ngefomu:
- i-rhinitis;
- i-asthma enzima;
- i-bronchitis;
- ukuqhuma okukhulu.
Kungase futhi kwakha ukusabela okujwayelekile (ngokuvamile ngesimo sokusakazwa kwe-anaphylactic).
Kungani futhi ukuhlaziya kanjani i-immunoglobulin E?
Ukuhlaziywa kwe-immunoglobulin E ejwayelekile kusetshenziselwa ukuxilongwa kwezifo ezihlukahlukene ze-atopic nezifo zokuthola izifo ezithathelwanayo. Ukuze uhlolisise ukungezwani komzimba, akwanele nje ukuthola ukuthi inani le-Ig E liphakanyisiwe egazini. Kubalulekile ukukhomba i-allergen causative kanye nama-antibodies othize ngokumelene nalo. Kodwa izinga lika-Ig E likuvumela ukuba uhlukanise ngokushesha izifo ezivuvukala ezivela ezifweni ezithathelwanayo ezinesithombe esifanayo somtholampilo, futhi nokuthola izifo ezibangelwa izifo zokwelapha futhi ukhethe ukwelashwa okwanele.
Ngaphambi kokuthatha i-immunoglobulin E jikelele, akukho ukuqeqeshwa okukhethekile okudingekayo. Kudingeka nje ukuthi ungadli ngaphambi kokuhlaziywa. Ngokuvamile, ukuhlola okunjalo kwelabhoratri kunqunyelwe ukuthi:
- ama-scabies ;
- isikhumba sesikhumba;
- itching.
I-urticaria engapheliyo futhi engapheliyo akuzona izinkomba eziqondile zokunquma inani le-immunoglobulin E, ngoba liyisimo esingenasigciwane.
Ukwenyuka kokuhlushwa kwe-IgE kubonisani?
Okubalulekile kokunqunywa kwe-immunoglobulin E isisindo segazi lonke. Amazinga aphezulu we-Ig E kuwo ayaqaphela lapho:
- I-pollinosis;
- ukudla kokudla;
- i-bronchitis ye-asthmatic;
- i-urticaria;
- I-Stevens-Johnson syndrome ;
- I-edema ka-Quincke;
- i-asthma ye-bronchial.
Ukwanda kwe-immunoglobulin E ehlala njalo kugcinwa nge-atopic dermatitis, ukugula kwe-serum, i-Lyell's syndrome kanye nezidakamizwa zokungabi namagciwane. Ngezinye izikhathi izinga le-Ig E liphakeme kunejwayelekile, uma umuntu ene-infestation ye-helminthic, isifo
Izici zokuchazwa kwemiphumela ye-Ig Ig ukuhlaziywa?
I-immunoglobulin ephelele ephansi ibonisa ukuthi umuntu une-ataxia-telangiectasia syndrome noma i-immunodeficiency. Ingabe imiphumela yokuhlaziywa evamile? Lokhu akufaki ukubonakala kokubonakaliswa kwe-allergen. Isibonelo, iziguli ezingu-30% ezinezifo ezingenayo i-atopic zinezinga le-Ig E ngaphakathi kwendabuko. Ngaphezu kwalokho, abanye abantu abane-asthma ye-bronchial bangaba nozwela ku-onegengen kuphela. Ngenxa yalokho, bane-Ig E ejwayelekile ingaba njalo ebangeni elijwayelekile.