I-Hypothiazide yisidakamizwa esiseqembu lama-diazio-thiazide aphakathi kwamandla. Umuthi unikezwa ngendlela yamathebulethi. Ngokuqhubekayo sizocubungula, ngukuphi ukusetshenziswa kwe-Hypothiazide kumathebulethi kuqokwe noma kukhethwe, yikuphi ukuphikisana kwawo kanye nemigomo yokuhambisa.
Ukwakhiwa kanye nesenzo semithi ye-Hypothiazide
Isithako esiyinhloko se-Hypothiazide yi-hydrochlorothiazide. Njengoba izinto eziwusizo ekubunjweni kwamaphilisi afaka izithako ezinjalo:
- i-talc;
- i-gelatin;
- i-magnesium stearate;
- isitashi;
- i-lactose monohydrate.
I-Hypothiazide iyi-diuretic, futhi, ngaphezu kwalokho, inomthelela omelene ne-antihypertensive ezingeni eliphezulu lokucindezela kwegazi. Isimiso sokusebenza kwezinyathelo zamathebulethi sihambisana nomphumela wokuvimbela i-hydrochlorothiazide ekusebenzeni kwe-epithelium ye-tubulus ye-renal. Lokhu kubonakala, ngokuyinhloko, ekunciphiseni ukuchithwa kwe-sodium, i-chlorine (kanye nenani elincane le-potassium ne-bicarbonates) kanye namanzi ahambisanayo. Kukhona nokuncipha kwe-uric acid ne-calcium ions nokunyuka kwe-i-magnesium ions. I-Hypothiazide yemithi inomthelela emithethweni ehlukahlukene ye-asidi-base balance of the body - kokubili nge-acidification (acidosis) kanye ne-alkalization (alkalosis).
Ngokunciphisa umthamo we-extracellular fluid etholakala ngokususa i-sodium, i-chlorine namanzi we-water, kanye nokwandisa imishanguzo encane, kwenziwa isenzo se-hypotensive. Kulesi simo, lesi sidakamizwa asinomthelela ekucindezeni kwegazi evamile futhi asibanga umphumela wokulutha. Isenzo se-Hypothiazide senyuka ngokukhuphuka ngokudla okusawoti. Futhi, lesi sidakamizwa sisiza ukunciphisa ukucindezelwa kwe-intraocular.
Uma usebenzisa isikhathi eside, imithi esebenzayo yomuthi isiza ukubambezela ukuphuma kwe-calcium ions ngezinso, okungaba nethonya elihle phambi kwamatshe enso equkethe i-calcium usawoti.
Izinkomba nokuphikisana kokusetshenziswa kwe-Hypothiazide
Amaphilisi e-Hypothiazid avame ukushiwo ukuvuvukala nokucindezela kwegazi eliphezulu. Ngokweziqondiso, uhlu olugcwele lwezinkomba zalesi sidakamizwa lungokulandelayo:
1. Izigaba ze-hypertension ze-Arterial I and II (njengendlela yokwelashwa kwe-monotherapy noma ngokuhlanganiswa nezinye izindlela zokwenza izinto ezingasebenzi).
2. I-Edema yemvelaphi ehlukahlukene, ehambisana no:
- i-nephrotic syndrome;
- isifo senhliziyo noma ukungakwazi ukusebenza kwe-renal;
- isifo sokucindezeleka kwangaphambili;
- i-cirrhosis yesibindi;
- glomerulonephritis enzima;
- ukwamukela izindlela ze-hormonal, njll.
3. Isidingo sokuvimbela ukukhishwa komchamo (ikakhulukazi ku-nephrogenic isifo sofuba).
4. Isidingo sokuvimbela ukwakheka kwamatshe emgqeni we-urinary.
5. I- glaucoma (ekwelapheni okunzima).
Ukuqhathaniswa kokuthatha i-Hypothiazide:
- i-anuria;
- ukuthukuthela okukhulu noma ukungakwazi kahle kwe-hepatic;
- isifo sikashukela sinesimo esibi;
- ukungeneliseki okunamandla;
- ukukhulelwa (I trimester);
- hypokalemia engqondweni, hyponatremia, hypercalcemia;
- i-hypersensitivity ezingxenyeni zomuthi.
Isilinganiso se-Hypothiazide
Umthamo wesidakamizwa ukhethwe kuye ngesimo sesifo kanye nemvelo yenkambo yayo. Amathebulethi kufanele athathwe ngemva kokudla.
Ezimweni eziningi, ngokucindezela okwedlulele, umuthi uthathwa ku-25-50 mg ngosuku. Umthamo womuthi we-edematous syndrome ungase ube ngu-25-100 mg, ne-Hypothiazide ethathwe kanye ngosuku noma zonke izinsuku. Uma kwenzeka i-edema enzima, isilinganiso sokuqala somuthi singase senyuke sibe ngu-200 mg ngosuku. E-premenstrual syndrome, njengomthetho, thatha amaphilisi angu-25 ngosuku.