Isifo somfutho wegazi ophezulu, noma isifo somfutho wegazi, yisifo esibhekene nokucindezela okwandayo ohlelweni lwe-pulmonary artery. Isizathu esiyinhloko salesi sifo ngokuvamile siyakhula ekumeni embhede wamasiphaphu wamaphaphu. Isici sesibili esingathinta ukuthuthukiswa komfutho wegazi ophezulu we-pulmonary is an increase in volume of pulmonary blood flow.
Ulwazi olujwayelekile mayelana nesifo
Umfutho wegazi ophezulu wegazi ophazamisayo uthinta abesifazane kabili njengezocansi eziqinile. Isilinganiso seminyaka yeziguli sineminyaka engama-35. Naphezu kokuthi le minyaka ingaqhubeka ibizwa ngokuthi intsha, emsebenzini wezinkinga ze-artery yamapayipi kungenzeka isivele ivele.
Umfutho wegazi ophezulu we-pulmonary ubhekisela ezifweni zomndeni noma izifo ezincane. Ukuze kuqondile, izimo eziphuthumayo, ezenzeka ngezikhathi ezithile futhi ezingavamile, zenzeka kaningi ngokuphindwe kabili kunomndeni.
Uma lesi sifo singokwemvelo, kunengozi enkulu yokuguqulwa kwesakhi se-receptor ye-bone morphogenetic protein type 2. Lokhu kungabangela inqubo yokwelapha.
Izimpawu ze-primary blood pressure
Izimpawu zomfutho wegazi ophezulu (idiopathic) we-pulmonary pulmonary eziningi:
- I-vasoconstriction ehlukile. Leli gama lisho ukuthi i-lumen yemithambo yegazi, ikakhulukazi imishanguzo, yancipha.
- Ukuqina kwemisipha emihle - ukuqina kwezindonga zegazi.
- Ukulungiswa kwezindonga zemithambo yegazi. Isibonakaliso sibonakalisa kunoma yiluphi uhlobo lwe-hypertension yomshuwalense, kuboniswa ngosizo lokuguqulwa okuguquguqukayo kwemisebenzi kanye ne-morphology yemithwalo yegazi. Ukulungiswa kwe-Vascular kuyisibonakaliso sokukhula kwesifo, ngakho lokhu kuthathwa ngokungathí sina kakhulu futhi impendulo iyashesha.
Ngaphezu kwalokho, i-vasoconstriction ibonisa ushintsho oluthile emzimbeni. Isibonakaliso siwumphumela wokunyuka komsebenzi we-thromboxane, endothelin nokuncipha kwesenzo esisebenzayo se-prostacyclin ne-nitric oxide. Ngakho-ke, ama-vasoconstrictors asebenza kakhulu, futhi ama-vasodilators anciphisa umsebenzi.
Izimpawu zokuqala ze-pulmonary hypertension
Isiguli sisesimweni sokunquma izimpawu ezijwayelekile ze-hypertension ye-pulmonary, ebonakala kuqala. Akunakwenzeka ukungaqapheli ukunyuka kwengcindezi yegazi ngesigamu. Isiguli sinokukhathala ngokweqile, ukuphefumula okuncane nokulayisha okujwayelekile futhi kuphazamise esifubeni, okuhambisana nokuphelelwa amandla . Lezi zimpawu zibizwa ngokuthi izibonakaliso ezingaqondile ze-pulmonary hypertension, ngoba zingabonisa ngezifo eziningi nezinkinga, ngakho-ke ngokuvamile aziqapheli.
Futhi, isiguli silahlekelwa isisindo ngisho nangokondla okugcwele, sizizwa sidiniwe, isimo sengqondo singase sibonakale sigxilile, ngisho nangaphandle kwezizathu zalokhu. Kulezi zibonakaliso ezicacile, ukukhwehlela okumile njalo kanye nezwi elihlabayo kungaqaphela. Okuhlangenwe nakho kobuchopho
Izimpawu zomshukela ophuthumayo we-pulmonary
Ifomu elilinganiselwe lesi sifo liyingozi kakhulu, ngoba izimpawu zalo azivezwanga kakhulu, ngenxa yokuthi zingatholakala yini ezinkathini ezisheshayo zokuqhubeka kwezifo. Isici esiyinhloko ukukhula kwengcindezi izikhathi ezimbili noma ngaphezulu uma kuqhathaniswa nomkhuba.
Ukubamba iqhaza, singasho ukuthi izimpawu zesifo esiyinkimbinkimbi zivuthiwe ngokwanele. Ekuqaleni, bangabulungiswa ngokukhathala, ukukhathala noma ukuguga. Kodwa ukuze ugweme izinkinga zempilo ezibucayi, kubalulekile ukubonisana nodokotela ngaphandle kokulibaziseka ngezinguquko zokuqala ezingalungile empilweni.