Amalungiselelo e-Bisphosphonate

Iklasi elikhethekile lemithi elivimbela ukulahleka kwethambo nokubhujiswa yi-osteoclasts lisetshenziselwa ukuphathwa ngokweqile kwabesifazane. Amalungiselelo e-bisphosphonate noma ama-dysphosphonate yizinhlanganisela ezenziwe ngendlela efana kakhulu ne-pyrophosphates yemvelo engahambisani ne-resorption. Namuhla zibhekwa njengemithi kuphela ye- osteoporosis ephumelelayo.

Amagama amalungiselelo eqembu le-bisphosphonate

Uhlobo lwemithi olubhekwayo lubalwa ngamaqembu amabili amakhulu - izidakamizwa ezine-nitrogen nezidakamizwa ngaphandle kwayo.

Izinhlobonhlobo zokuqala zihlanganisa:

1. I-alendronic acid. Ivuselela kakhulu ukubuyiselwa kwesakhiwo nokubunjwa kwesakhiwo esiqondakalayo samathambo, ilawula ukushintshaniswa nezinqubo zokubuyisela kabusha. Ngokuvamile kuvunyelwe ukuxoshwa kwe-senile ne-post-menopausal, i-hypercalcemia engafanele futhi i-deforming osteitis, ukuvimbela ama-fractures;
2. I-Zolendronate noma i-zoledronic acid. Iqeda umsebenzi we-osteoclasts, kodwa ayithinti izinqubo ze-bone mineralization, izakhi zomshini kanye nokwakheka kwezicubu;
3. I-clodronic acid (i-Clodron, i-Bonefos). Iyanciphisa ingozi yokuphulwa kwamathambo, ikhiqiza umphumela wokubulala umzimba. Isetshenziselwa imithi yokuhlola, ngokukhetha ukubhubhisa ama-macrophages we-pathological;
4. I-Bondronate (Ibadronic acid). Yakhelwe ngokukhethekile ukwelashwa kwabesifazane, ikakhulukazi efanele esikhathini esibucayi. Futhi isetshenziselwa ukwelashwa kwe-hormonal esikhundleni.

I-Bezazotistye bisphosphonates ingathathwa ngama-metastases emathanjeni, izinhlobo ezinzima zezicubu ezimbi, hypercalcemia. Kulokhu, ukukhetha okulungile yisilinganiso esifanele, okufanele udokotela abale kuso. Ngaphandle kwalokho, ikakhulukazi ngokudlula ngokweqile, izinkinga zingase zenzeke.

Uhlu lwamalungiselelo ama-bisphosphonate ngaphandle kwe-nitrogen:

1. I-Tiludronate. Ukwandisa ubukhulu bezinthambo zamathambo, ngakho-ke kuvame ukushiwo phambi kokukhubazeka nokuhlukumeza;
2. Xidiphon, Pleistat noma i-sodium etidronate. Liyasetshenziswa kakhulu ekwelashweni okuyinkimbinkimbi kwesifo sikaPaget, izifo ezingokwemvelo, i-hypercalcemia, i-osteoporosis enkulu;
3. I-sodium ibandronate. Kuyasiza kahle ngezidakamizwa ze-hormonal for treatment substitution esikhathini sokuthunyelwa kwamadoda;
4. Clodronate. Ukuvimbela ukubhujiswa kwama-crystal calcium, ukuthuthukiswa kwe-osteolysis. Isidakamizwa sinqunywe izicubu ezincelisayo ze-tumor, i-leukemias, i-lymphomas, ama-metastase amaningi.

Ukufundiswa kwe-bisphosphonates

Ukwamukelwa kwemithi echazwe ngenhla kwenziwa ngokuvumelana nezincomo zesidokotela 1 isikhathi ngosuku.

Ama-bisphosphonates awanamathele kakhulu, ngakho-ke kudingeka adakwe ngamanzi abilisiwe ahlanzeke kakhulu ekamelweni lokushisa ukuze athole ukukhishwa okungcono.

Kuyinto efiselekayo ukugcina ikhefu phakathi kokungena ukudla kanye nezidakamizwa ze-bisphosphonate. Amathebulethi kufanele athathwe amahora angu-1,5 ngaphambi kokudla esiswini esingenalutho - akukho ngaphambi kwamaminithi angu-60 ngemva kokudla.

Esinye sezici ezingathandeki zalesi sigaba semithi yikhono labo lokucasula i-mucosa yesifo, ukuvusa ukwakhiwa kwezilonda ezincane phezulu. Ngakho-ke, emva kokuthatha ama-bisphosphonates awukwazi ukulala ngokushesha, kubalulekile emaminithini angu-90 (ubuncane) ukuba ube endaweni eqondile, ungahlala, kodwa kungcono ukuhamba ngezinyawo noma nje ukwenza imisebenzi yasendlini. Lokhu kuzokuvimbela imiphumela emibi efana nokushaya inhliziyo , ukuguqula kabusha i-reflux ne-esophagitis.