Emithini yesimanje nemithi yesimanje, ezinye izinto ezitholakele zenzeka njalo. Konke kwenziwa ukuze kube lula ukwelashwa kwezifo ezithile. Enye yezinto ezithembisayo kakhulu ezithathwe yi-antioclonal antibodies. Ama-antibodies amaningi akhiqizwa ngumzimba ayenziwa nge-polyclonal. Kulula nje, zenzelwe ukulwa nama-antigens ahlukene, okunciphisa kakhulu ukuphumelela kokwelashwa. Ama-antibodies a-monoclonal enza ngenhloso, evumela ukuthola umphumela omuhle kunabo bonke.
Isimiso sokwelapha nge-antibodies monoclonal
Kuze kube manje, amasosha omzimba amancane asetshenziselwa ukwelashwa okuhloswe noma okuthiwa okuhlosiwe. Njengoba izivivinyo ziboniswa, le ndlela ibonisa imiphumela engcono kakhulu yokwelapha.
Ama-antibodies angama-monoclonal angama-antibodies avela ku-clone eyodwa yeselula. Okungukuthi, bonke banesisodwa esisodwa esandulela iseli. Ama-antibodies aseMonoclonal asetshenziselwa:
- i-colitis ;
- i-arthritis ye-rheumatoid;
- i-psoriasis;
- multiple sclerosis .
Basiza ukulwa ngisho nezinhlobo eziyinkimbinkimbi kakhulu ze-oncology.
Isimiso sokusebenza kwamagciwane e-monoclonal asilula: baqaphela ama-antigens athile futhi anamathisele kuwo. Ngenxa yalokhu, amasosha omzimba ngokushesha aqaphela inkinga futhi aqala ukulwa nalo. Eqinisweni, amantombazane omzimba avikela umzimba ukuba alahle ama-antigen ngokuzimela. Enye inzuzo enkulu ye-MCA ukuthi ithinta amangqamuzana angaguquguquki ngaphandle kokulimaza impilo.
Ama-antibodies e-monoclonal ku-oncology
Kulezi ziguli eziningi ezine-oncology, izidakamizwa ezibandakanya ama-antibodies monoclonal zibe yithemba elilodwa lokubuyela ejwayelekile. Ingxenye enkulu yeziguli ezinezicubu ezinkulu ezibuhlungu kanye nezibikezelo ezidumazayo ngemuva kokuthola ukwelashwa zizwakala ukukhululeka.
Izinzuzo ze-ICA ziyabonakala:
- Ukuxhunyaniswa namangqamuzana omdlavuza, amasosha omzimba omzimba angabonakali kuphela, kodwa futhi ayancipha. Futhi ngamaseli aguqulwe ngokuguqula umzimba, umzimba ulula kakhulu ukulwa.
- Ama-antibodies e-monoclonal athola inhloso yawo anegalelo ekuvimbeleni ama-receipt of growth tumor. Ngenxa yalokhu ukwelashwa kwe-oncology kulula kakhulu.
- Ama-antibodies atholakala ebhokisatri, lapho ehlangene ngqo ne-small amounts of particles radioactive. Ukudlulisa lezi zinhlayiya emzimbeni, i-MCA izinikela ngokuqondile ku-tumor, lapho isebenza khona.
Ukwelashwa komdlavuza nge-antiocidal monoclonal kungafaniswa ne-radiotherapy. Kodwa ngokungafani nalokhu okulandelayo, i-ICA yenza izinto ezinzima. Inhloso yabo yenza kube lula ukusebenzisa inombolo encane kakhulu yezinhlayiyana ezivuthayo.
Izidakamizwa eziqukethe ama-antibodies monoclonal
Naphezu kokuthi i-ICA yaqalwa kungekudala, uhla lwamalungiselelo aqukethe lawo kakade lubonakala luhle kakhulu. Imithi emisha ivela njalo.
Ama-antibodies ethandwa kakhulu e-monoclonal asetshenziselwa namuhla i-psoriasis, i-multiple sclerosis, umdlavuza, i-rheumatoid arthritis, i-colitis ibonakala kanje:
- Alemtuzumab;
- I-Alefacept;
- Daclusimab;
- Okrelizumab;
- Ustenkinumab;
- Basiliximab;
- Ofatumumab;
- I-Epratuzumab;
- I-Clenoliximab;
- Bevacizumab;
- I-Trastuzumab;
- Adalimumab;
- Enbrel;
- I-Infliximab nabanye.
Yiqiniso, ama-antibodies omzimba, njengezinye izidakamizwa eziningi, angaba nemiphumela emibi. Ngokuvamile, iziguli ngemva kokusebenzisa i-ICA zikhononda ngokubonakaliswa kokuphendula okubangelwa ukugula: ukushaya, ukushisa. Ezimweni ezingavamile, ukwelashwa kuhambisana ne-nausea, ukuhlanza noma isifo segciwane.