Isici se-necrosis ye-tumor ibizwa ngokuthi amaprotheni amaningi e-extracellular, akhiqizwa ngamangqamuzana angenamsoco (macrophages, eosinophils). Ngokwenza kwamanye amaseli omzimba, le protheyini ibangela imiphumela elandelayo:
- ukusheshisa kwe-lipid metabolism;
- shintsha ekupheleleni kwezindonga zegazi;
- ukukhiqizwa kwe-interleukins (1, 6, 8);
- ukuvikelwa ezimpandeni ze-intracellular;
- ukulawulwa kokukhiqizwa kwama-antibody;
- umphumela we-antitumor.
Ukuhlolwa kwegazi ngenxa ye-tumor necrosis factor
Njengoba isifo se-necrosis se-tumor sithatha cishe cishe wonke ama-immune ukusabela komzimba, ukugxilwa kwalo egazini kunqunywa ukuqina kwezinqubo zokuvuvukala. Uma ukuhlolwa kwegazi kubonisa ukuthi inkinga ye-necrosis ye-tumor iphakanyisiwe, khona-ke lokhu kungabonisa izifo ezinjalo:
- izifo ezithathelwanayo ezinzima (isibindi C, ukutheleleka kwe-herpes, endocarditis, njll);
- i-sepsis ;
- isimo sokwethuka okukhulu;
- ischemic isifo senhliziyo;
- i-psoriasis;
- izifo eziphilayo;
- ukusabela ukulahlwa kwezitho zokufakelwa;
- ukuqina kwe-atherosclerosis ye-artery of the heart and the brain;
- i-pathologies engapheliyo ye-bronchopulmonary;
- izifo ezizimele ;
- izifo ezithathelwanayo, njll
I-necrosis ye-tumor iyinxenye ye-oncology
Ukunquma inani le-necrosis ye-tumor kubalulekile ekuhloleni inkambo yomdlavuza. Ngokuphathelene namangqamuzana e-tumor, le phrotheni ibonisa umsebenzi, ovezwa nge-necrosis enegazi elimangqamuzana wamangqamuzana angenawo ama-nonoplastic ngaphandle kokubhubhisa amaseli aphilile. Ngenxa yesifo se-necrosis se-tumor esinqunyiwe ngendlela ekhethekile evela egazini le-donor, izidakamizwa ezinezakhi ezithuthukisiwe ze-antitumor zikhiqizwa, kanti zinezimo ezinobuthi ezincane emzimbeni. Isibonelo, ngosizo lwesidakamizwa Ukunakekelwa kwe-Refnot yomdlavuza webele kwenziwa.