Izidakamizwa ezingekho-steroidal anti-inflammatory - uhlu

Izidakamizwa ezingezona ukuvuvukala (ama-NSAID) yiqembu lemithi ephumelelayo ene- antipyretic, anti-inflammatory and analgesic effect.

Ngakho-ke, lezi zidakamizwa zisiza ukunciphisa ubuhlungu, umkhuhlane nokuvuvukala. Isenzo sabo sisekelwe ekuvimbelweni kwe-enzyme ethile, lapho ukuhlanganiswa kwezinto ezithinta inqubo yokuvuvukala kwenzeka emzimbeni. Ngokungafani ne-glucocorticoids (ama-hormone agents), umphumela wawo ofanayo, imithi yobuhlungu obungenayo i-steroid ayinayo inqwaba yezinto ezingathandeki.

Ngaphezu kwalokho, ezinye ze-NSAID zinomthelela wokulwa nokuhlukunyezwa (ukususwa, ukuthuthukiswa kwegazi), kanye nomphumela wokuzivivinya umzimba (ukucindezelwa kokuzivikela komzimba).

Izinkomba zokusetshenziswa kwama-NSAID

Ngokuvamile, izidakamizwa ezingekho-steroidal anti-inflammatory zisetshenziselwa izifo ezinzima nezihlala njalo, ezihambisana nokuvuvukala nobuhlungu. Ake sibhale izinambuzane eziningana, lapho kulungiselelwa khona amalungiselelo alandelayo eqembu elinikeziwe:

• i-osteoarthritis;
• i-arthritis ye-rheumatoid;
• i-gout;
• ikhanda, i- migraine ;
• umkhuhlane;
• izifo zezinzwa;
• i-dysmenorrhea;
• i-renal colic;
• ukuguqulwa kwamathambo;
• isifo se-postoperative syndrome;
• ukuphefumula kwamathambo.

Uhlu lwezidakamizwa ezingekho-steroidal ezilwa nokuvuvukala

Uhlu lwezidakamizwa zesimanje ezingezange-steroidal ezilwa nokuvuvukala manje lukhulu kakhulu. Zihlukaniswa ngokuvumelana nesakhiwo samakhemikhali kanye nemvelo yomsebenzi. Izinhlobo ezahlukene zezidakamizwa ezingekho-steroidal ezilwa nokuvuvukala zihlukaniswa: amaphilisi, amakhemikhali, amafutha okugcoba, ama-gel, ama-suppository, izixazululo ezingenakulungiswa, njll.

Cabanga ngezinhlobo eziyinhloko zama-NSAID:

1. Ama-salicylates:

• I-Aspirin;
• I-Diflunisal;
• i-lysine monoacetyl salicylate.

• Indomethacin;
• Sulindak;
• Lona yi-eelander.

• Diclofenac ;
• I-Aceclofenac.

• Ibuprofen;
• Ketoprofen;
• I-Tiaprofenic acid;
• I-Naproxen;
• I-Flurbiprofen;
• Fenbufen;
• I-Fenoprofen;
• Nabumethon.

• Lornoxicam;
• I-Tenoxicam;
• I-Piroxicam;
• Meloksikam.

• Rofecoxib;
• I-Nimesulide;
• Celecoxib.

Kusukela emalungiselelweni anikeziwe ngesenzo sokuhlaselwa, izidakamizwa ezifana neKetorolac, Ketoprofen, Diclofenac, Indomethacin ziphumelela kakhulu. Izakhiwo ezinhle kakhulu zokulwa nokuvuvukala yi-Indomethacin, i-Flurbiprofen, iDiclofenac ne-Piroxicam.

Kumele kuqaphele ukuthi izidakamizwa ezingezona izidakamizwa ezingezona ukuvuvukala zithengiswa ngaphansi kwamagama ahlukahlukene ezohwebo. Ngakho-ke, uma uthenga umuthi ekhemisi, okokuqala, umuntu kufanele aqaphele igama lamazwe ngamazwe.

Izidakamizwa ezingezona ukuvuvukala kwezizukulwane ezintsha

Izidakamizwa ezingezona ukuvuvukala zalesi sizukulwane esisha zisebenza ngokukhetha futhi zibonisa umsebenzi ophezulu uma kuqhathaniswa nabandulela. Kulesi simo, cishe akukho nemiphumela emibi evela emathangeni omzimba.

Abamele imithi emisha yeqembu le-NSAID yi-oxycam. Ngaphandle kwezinzuzo ezingenhla, lezi zidakamizwa zibhekwa ngokunyuka kwengxenye yokuphila, ngenxa yokuthi isenzo somuthi singakanani isikhathi eside. Impendulo kuphela yalezi zidakamizwa yindleko ephezulu.

I-NSAID nayo inezinkomba zabo:

• izilonda ezinomsoco nezilonda zesisu somathunjwa;
• ukuphulwa kwebindi nezinso;
• i-cytopenia;
• ukukhulelwa;
• ukungaboni ngaso sonke isikhathi.