I-Adrainolitics yiqembu lamakhemikhali alithinta ama-receptor athile. Kuye ngokuthi yiziphi izidakamizwa ezithintekayo lezi zinto, zihlukaniswe zibe yi-beta kanye ne-alpha-blockers. Ukulungiswa okusekelwe kubo kunqunywe ekulwa nokuphikisana okuhlukahlukene kwenhliziyo, isimiso sezinsiza, uma kwenzeka ukuphazamiseka kokujikeleza kanye nokugcizelela ukucindezela.
Ukulungiselela Alpha-blockers
Kunezinhlobo ezimbili eziyinhloko zemithi.
Abavimbela abangekho okhethwayo
Izinto zicindezela umsebenzi we-postsynaptic adenoreceptors, okuholela ekunwetsheni kwe-lumen yemikhumbi nokudonsa kwengcindezi, kanye nokukhululwa ngokweqile kwe-norepinephrine.
Ummeleli oyinhloko eqenjini lokuqala yi-Fentolamine, okusebenza ngayo ukwandisa imikhumbi yangaphandle. Uma lo muthi uphathwa ngendlela engaphakathi, umphumela utholakala kungakapheli imizuzu eyishumi nanhlanu.
Ezokwelapha, imithi manje isetshenziswe ngokungajwayelekile, kodwa ingahle ibekwe:
- ukulala noma isithwathwa;
- ukuxilongwa kwepheochromocytoma;
- Inkinga enkulu;
- ukuphazamiseka okukhulu;
- Isifo sikaRaynaud .
Abanye abamele leli qembu:
- I-Pyrroxane;
- ITropafen;
- I-Dihydroergotamine.
I-Alpha-1-adrenoblockers ekhethiwe
Izinto zibhekene nomsebenzi omkhulu nesikhathi eside. Zinefuthe elihle ezingeni le-cholesterol egazini, ngaleyo ndlela ukunciphisa ingozi yokuthuthukisa isifo sokuqina kwamathambo. Ngaphezu kwalokho, izinto aziphazamisi okuqukethwe okushukela, ungakhulisi ukucindezela futhi uhluke kwinani elincane lemiphumela emibi.
Ama-alpha-blockers akhethiwe ahlanganisa uhlu olulandelayo lwezidakamizwa:
- Doxazosin;
- Ter;
- Prazon.
Ngokwenza kahle, lezi zidakamizwa zide kakhulu ngaphambi kweFentolamine. Umphumela wabo oyinhloko ukunciphisa ingcindezi ngokunciphisa ukucindezelwa kwethambo lezinthambo. Izakhiwo ziqala ukubonakalisa emva kwehora elilodwa ngemuva kokungenisa.
Izinkomba zokusetshenziswa kwe-Alpha-adrenoblockers
Cabanga ngemiphumela yokwelapha yamaqembu athile wezidakamizwa:
- Ngama-pathologies ohlelweni lokujikeleza komzimba (isifo sikaRaynaud), ekwelashweni kwamailonda okuphulukisa isikhathi eside kanye ne-decubitus, futhi ekulawuleni ipheochromocytomas, i-Fentolamine neTropafen inqunywe.
- Izigaba zokuqala zokuthuthukiswa kwe-prostate adenoma ziphathwa nge-Prozazin, okuthuthukisa ukuphuma komchamo.
- I-Alfa-1-adrenoblockers yayivame kakhulu e-hypertension. Bayandisa izitsha (kusukela ezincane kunazo zonke kuya ezikhulu kunazo zonke), ngaleyo ndlela banciphise ukucindezela. Ukunciphisa ukucindezeleka kuholela ekudakeni okuphawulekayo emithini yemotocardium, okwenza lezi zidakamizwa zisebenze ngokuphumelela kwe-myocardial infarction .
- Ukusebenzisa ukwelapha isikhathi eside, iPrazonin neDoxazine zisetshenziswa.
- Izakhiwo ze-Fostopolitic zinikezwa uFentolamin noPrazonin.
- I-Diabergergotamine isetshenziselwa i-migraine, kanye nezinhlobo ezimbi nezivulekile zokungasebenzi kahle kwegazi.
Ukungafani kwe-Alpha-blockers
Unganiki imithi kubantu abanokuhlukana okulandelayo:
- i-bradycardia;
- i-atherosclerosis enkulu;
- izinhliziyo zomzimba;
- ngesifo sezinso;
- ukuqhuma kwesifo sokushukela, isici kubantu asebekhulile abanesifo sikashukela;
- ischemic isifo ngaphandle kokuphathwa okufanayo kwe-beta-blockers;
- ukwelashwa kokusakaza kwe-cerebral.
Ukuphikisana okuhambisanayo kukhulelwa.
Imiphumela engathandeki ibonakala njenge:
- ukucindezela ngokweqile kwengcindezi;
- ukuqala kokuvuvukala;
- ikhanda;
- izinga lokushaya kwenhliziyo;
- i-tachycardia;
- i-vasodilation;
- ukuvuvukala kwezinambuzane ezimangcwaba;
- isicasuli;
- ukulala;
- ubuhlungu emisipha.