I-Angiotensin-eguqula i-enzyme iguqula i-angiotensin-Mina ngiyi-angiotensin II. Futhi lesi sigaba, njengoba kuyaziwa, siphakamisa ukucindezelwa kwegazi kubantu. Lokhu kwenziwa ngokunciphisa izitsha, kanye nokuphonsa i-aldosterone. Ukuze uvimbele i-angiotensin, i-ACE inhibitors ingahle ibekiwe.
Ngakho-ke, izidakamizwa ze-ACE inhibitor zingama-antihypertensive asemukelwe ngempumelelo iminyaka engaphezu kwengu-30 ephakeme yegazi. Ukwandisa umphumela we-inhibitor kuneluleka ukuba uthathe ngokubambisana ne-diuretic.
Ukuhlukaniswa kwe-ACE inhibitors
Uma uhlukanisa izixazululo, ukuhlukaniswa okuhlukile kuyasetshenziswa. Ngakho-ke, ngokusho kwesikhathi somthelela, lawo maqembu ezidakamizwa ayahluka:
- Ukuvezwa kwesikhashana. Ukusebenza kwalezi zimali kuthatha amahora ama-5-6. Uma ungathathi iphilisi elilandelayo ngesikhathi, kungaba khona ukugxuma okubukhali ekucindezelweni phezulu. Zihlanganisa, isibonelo, i- Captopril , okumele ithathwe izikhathi ezintathu ngosuku.
- Kusho ngethonya elihlala njalo. Zisebenza kahle ngamahora angu-12. Bhala lezi zidakamizwa kabili ngosuku - ngokuvamile ekuseni nakusihlwa. Ummeli omkhulu waleli qembu lamaphilisi-inhibitors we-ACE - Enalapril .
- Imithi imila isikhathi eside. Lezi zimali zamukelwa ngezikhathi ezithile kanye ngosuku. Kodwa-ke, ezimweni ezibucayi, ukwamukelwa kwesikhathi ezimbili nakho kungenzeka. Leli qembu lihlanganisa uRamipril , uLisinopril nabanye. Eqenjini elifanayo lemithi kukhona nalawo, umphumela wawo ogcinwe kuze kube amahora angu-48 emva kwephilisi lokugcina.
Ukucabangela izici ze-pharmokinetic, amaqembu alandelayo ayahlukaniswa:
- imithi lapho isithako esisebenza khona sikhona;
- ama-prodrugs.
Futhi, i-ACE inhibitors yesizukulwane esisha ihlukaniswa ngokulandela indlela elandelayo yokuqeda:
- ukuqedwa izinso (ngomyalelo we-70%);
- ukuphuma ngaphandle ngokusebenzisa uhlelo lwe-urinary ne-cholagogic;
- Ukuqedwa ne-bile ngokusebenzisa ipheshana lesisu.
Ukuhlukaniswa kwezidakamizwa okunjalo kungcono ngoba udokotela angakwazi ukubeka kahle ukuthi yini efanelekile kulolu gulane oluthile ohlwini lwamadivayisi wezokwelapha. Zonke izinzuzo zokulungiselela kanye nokuzikhethela komphumela walo emzimbeni zibhekwa lapha.
Imiphumela emibi ye-ACE Inhibitors
Ngisho ne-ACE inhibitor engcono kakhulu inika imiphumela eminingi emibi:
- ukukhwehlela okukhulu, okubangelwa ukuqoqwa kwe-bradykinin ohlelweni lokuphefumula;
- i-hypotension ;
- ubuthakathaka jikelele;
- ukunambitheka okuqondile emlonyeni;
- ukuphakama ku-creatinine;
- I-Hyperkalemia, izinga layo elijwayelekile ngokuthatha izidakamizwa;
- ukuhlukunyezwa;
- ukuhlukumeza kwezifo ezihlangene, njll.
Ukubukeka okungenani okukodwa kwalolu hlu lwemiphumela emibi kungesizathu sokuxhumana ngokushesha nodokotela ozofika ukuze athathe omunye umuthi. Uma ungayinaki leyo alamu noma uzama ukhethe izidakamizwa ngokwakho, ungangcwina kuphela isimo.
Ukungafani kokungenwa kwe-ACE inhibitors
Kunemibandela eminingi lapho ukusetshenziswa kwemithi ye-ACE inhibitors kuvinjelwe khona. Lokhu kufaka:
- ukukhulelwa;
- izinkinga zenhliziyo;
- ukuqina kwesithambo esiya ezinso;
- i-hyperkalemia;
- i-arthritis;
- isikhathi sokulahlwa;
- i-hypotension;
- ukubekezelelana nokunye.
Kuzo zonke izimo ezingenhla, ukuphathwa kwezidakamizwa ze-ACE inhibitor kulungele kuphela uma omunye ukwelashwa kungasebenzi. Kulokhu, udokotela emva kokuhlolisisa isiguli kumele alinganiswe nezingozi nezinzuzo zangempela.