Ukwehlukaniswa kwamaplatelet ngesikhathi sokukhulelwa kungenye yezinkomba ezibaluleke kakhulu, ukunciphisa okungaholela ekusenikeni kwegazi. Ukugxila emithini yezokwelapha kubhekisela ekwenzeni amaplatelet ukujoyina, okusho, ukufaka amaplatelet wegazi.
Le nqubo ilandelayo. Uma izindonga zezimpahla zonakalisiwe, igazi liqala ukugeleza kusuka kubo ukuvimbela imiphumela, umzimba uthumela i-alamu kumaseli. Ngenxa yalokho, endaweni yesimonakalo, ama-plateslet avela futhi, ehlangene ndawonye, vala izikhala emkhunjini.
Ukuze unqume le nkomba, i- coagulogram yenziwa-ukuhlolwa kwegazi usebenzisa indlela ye-laboratory esebenzisa ama-inducers-izinto ezikhethekile ezivusa ama-aggregation. Umkhuba we-aggregation weplatelet ngesikhathi sokukhulelwa lapho uxhumana nanoma iyiphi yalezi zinto zingama-30-60%.
I-hypoaggregation yamaplatelets ngesikhathi sokukhulelwa
Ukunciphisa ama-platelet aggregation ngesikhathi sokukhulelwa kungenzeka ngenxa yokubhujiswa okwedlulele noma ukusetshenziswa kwamaplatelet wegazi. Izimbangela zalokhu kungaba ukuphuma kwegazi njalo, ukwephula isimiso somzimba sokuzivikela komzimba, noma ukudla okungalungile kowesifazane okhulelwe. I-hypoaggregation yamaplatelets ngesikhathi sokukhulelwa iboniswa izimpawu ezifana nokulimaza nokuphuma kwegazi. Ezimweni ezinjalo, amapuleti egazi akhiqizwa ngamanani amancane kakhulu, noma athole isakhiwo esingavamile. Ekubelethweni okunjalo inkomba yegazi coagulability ingaholela ekuguleni okukhulu.
I-hyperaggregation yamaplatelet ngesikhathi sokukhulelwa
Ukunyuka okuncane kubhekwa njengenqubo yemvelo ngesikhathi sokubeletha - lokhu kuhlotshaniswa nokujikelezwa kwe-utero-placental. Ukwehliswa kwama-platelet ngesikhathi sokukhulelwa kungabangela ukubunjwa kwe-thrombi. I-thrombosis, i-arterial or venous, ingase ihambisane ne-antiphospholipid syndrome, okuyinto evame ukuba imbangela yokuhlukumeza kwamaphesenti ekuqaleni.