Izitatimende - "for" futhi "ngokumelene"

Amazinga aphakeme we-triglycerides ne- cholesterol egazini abhekwa njengesimo esiyingozi esingashukumisa ukuthuthukiswa kwezifo zenhliziyo. Ukunciphisa ukuhlushwa kwalezi zinhlanganisela kunikezwe izidakamizwa ezikhethekile, kuthathwe izifundo ezide. Kubalulekile ukuba isiguli sihlole zonke izimpikiswano ngaphambi kokuphuza izitho zomzimba - ukuphika nokuphambana, qaphela imiphumela emibi yale mithi kanye nezinkinga zokwelapha.

Izinzuzo kanye nokulimala kwama-statins omzimba

Ukukhiqizwa kwe-cholesterol kunezigaba eziningana zangaphambili ngokuthuthukiswa kwe-enzyme okuthiwa i-mevalonate. Izitatimende ziphazamisa ukwakheka kwawo ekuqaleni, ngakho-ke, ukuvimba ukukhiqizwa kwe-triglycerides ne-cholesterol.

Phakathi nocwaningo lwezokwelapha nokuhlolwa, kwatholakala ukuthi izidakamizwa ezibuzwayo zinemiphumela emihle elandelayo:

1. Ukunciphisa inani le-cholesterol e-plasma yegazi (inani - ngo-35-45%, eliyingozi - ngo-45-60%).
2. Ukunciphisa ingozi yezifo zesimiso senhliziyo, ukuvimbela ukuhlasela kwenhliziyo, ukushaya kwesifo sofuba, ukushaya, ukuhlaselwa kwe-ischemic.
3. Ukuqedwa kokwakhiwa kwe-cholesterol eklanyeni kwesibindi.
4. Ukwandisa ukuhlushwa kwe-apoliprotein A kanye ne-cholesterol ewusizo.

Futhi, ukusetshenziswa kwezitho zomzimba ukuthuthukisa impilo yeziguli ngisho nangaphambi kokuba kutholakale izifo zenhliziyo ngokuqinisa nokuhlanza izindonga zemithambo yegazi. Ngesikhathi esifanayo, le mithi ayinayo i-mutagenic kanye ne-carcinogenic effect.

Naphezu kohlangothi olubonakalayo oluhle lwemithi echazwe, osanda kuthiwa abachwepheshe basho okuncane kakhulu. Lokhu kungenxa yeminye imiphumela emibi yokuthatha izitembu:

1. Nciphisa ezingeni lokulimaza hhayi kuphela, kepha futhi ne-cholesterol engqikithi, edingekayo ekusebenzeni okujwayelekile komzimba, ukugcina ukuqina kwemithambo yegazi.
2. Imiphumela emibi e-parenchyma yesibindi ekunciphiseni ukukhiqizwa kwama-enzyme okuphambili kwe-cholesterol.
3. Ukuphola okusheshayo kokuqala kokugxila kwe-cholesterol ekupheleni komkhakha wokwelapha, okubangela ukuba iphilisi ithathe cishe yonke impilo.

Ngaphandle kwalezi zinkinga, kunezinye izinkinga eziningana ezimbi kakhulu ezidakamizwa.

Imiphumela emibi yengozi yama-statins

Izinto ezivame kakhulu:

• i-asthenic syndrome;
• isicasuli;
• ukulala;
• ukuqotshwa;
• ikhanda;
• flatulence;
• isifo sohudo;
• i-myalgia;
• ubuhlungu besisu;
• i-migraine;
• ukushayeka okuvamile, ubuthakathaka;
• i-paresthesia ne-hypoesthesia;
• isiyezi;
• i-peripheral neuropathy;
• iziqephu ze-amnesia;
• i-pancreatitis;
• i-jaundice yama-cholestatic;
• ukuhlanza;
• i-hepatitis;
• i-anorexia;
• ukuxubha;
• i-spasms emisipha;
• i-myositis;
• i-arthritis yamalunga amakhulu;
• ukuzithemba;
• ubuhlungu ekholini lomgogodla;
• i-erythema exudative;
• ukuphuza esikhumbeni;
• i-anaphylaxis;
• i-urticaria nokushaywa;
• I-Lyell's syndrome ;
• isifo sikashukela mellitus;
• i-thrombocytopenia;
• i-hypoglycemia;
• ukukhuluphala;
• i-edema yedolobha.

Phakathi kwemiphumela emibi kakhulu emibi yesimiso, kukhona ukuphazamiseka kwengqondo okuqhubekayo. Ukuhlolwa okuningi kuye kwabonisa ukuthi ezimweni eziningi zokwelashwa nezidakamizwa zibhekwa, ukukhubazeka kwememori, imisebenzi yokukhuluma, umsebenzi wokucabangela nokuhamba. Ezinye iziguli zihlushwa ukuhlaselwa okwesikhashana kwe-amnesia, lapho umuntu engakwazi ukwakha izinkumbulo zokugcina.

Ngakho, ukuthatha ama-statins kuyadingeka kuphela ezimweni ezimbi kakhulu:

1. Isifo se-Ischemic ne-ingozi eyanda kakhulu yokushaywa isifo noma isifo senhliziyo.
2. Ukwelashwa kwe-acute coronary syndrome.
3. Ukuhlinzwa kabusha ekwakheni imikhumbi noma inhliziyo.