Kungani umzimba udinga i-GSBG?
Emzimbeni womuntu, i-testosterone ijikeleza, ikakhulukazi efomini eliboshiwe, ngokubambisana ne-GHPS, kaningi, nge-albinini. Ukuhluka okufanayo kokubopha kwe-SHBG kuthinta ukuxilongwa kwe-testosterone egazini.
Izinga lokubambisana, i-SHGG ngqo, lixhomeke ekuhlungeni kwama-hormone ocansi. Ngakho-ke, ukwandisa izinga le-estrogen kwandisa ukuhlanganiswa kwalo. Ngakho-ke, okuqukethwe kwaleli hormone egazini labesifazane liphindwe kabili kunalo lamadoda. Kanye nokunciphisa ekukhiqizweni kwe-estradiol, okuqukethwe kwe-SHBG egazini labesifazane kunciphisa.
Okuqukethwe kwe-SHBG kunqunywa kanjani kwabesifazane?
Ngesinye isikhathi abesifazane abelwa ukuhlaziywa kwe-SHGG bayazi ukuthi kuyini, nokuthi bangayichaza kanjani imiphumela yabo - abanalo ulwazi. Okokuqala, kubalulekile ukwazi ukuthi yiliphi i-SHBG okufanele libe yinto evamile kwabesifazane. Kumele kuphawulwe masinyane ukuthi ukuhlushwa kwalo egazini akuzinzile, futhi kuncike ezintweni eziningi. Ukwanda noma ukwehla kwawo kungabonakala ezimweni zokugula.
Izinguquko ezingeni le-hormone liyabonakala njengoba iminyaka ikhula. Ngakho-ke, kwabesifazane:
- Iminyaka engu-8-10 - 26-128 i-nmol / l;
- 10-12 - 16-112 nmol / l;
- Iminyaka engu-12-14 - 19-89 nmol / l;
- Iminyaka engu-14-60 - 18-114 i-nmol / l.
Kanti futhi ukutholakala kwezifo kuvame ukusetshenziswa, okuthiwa i-IST (i-testosterone yekholi yamahhala). Kuboniswa ngesilinganiso se-testosterone esiphelele emzimbeni womuntu ku-SHGG. Ngakho-ke, kwabesifazane lolu hlu luhluka phakathi kuka-0.8-11%, kumadoda liyi-14.8-95%.
Kungani izinga le-SHBG egazini labesifazane linganda?
Ngokuvamile kunesici lapho izinga le-SHBG kulabo besifazane egazini landa khona. Okokuqala, kungabangelwa yi:
- ukwanda ekugxilweni kwe-estrogens egazini lomfazi;
- isimo se-hyperthyroid - esibonwe emzimbeni wegciwane le-thyroid;
- i-hepatitis;
- Ukutheleleka nge-HIV;
- ukwamukela izitho zokwelapha ze-hormonal, eziningi zazo eziqukethe ama-estrogens.
Ngenxa yalokho ukwehla kwezinga le-SHBG egazini?
Kulezo zimo lapho i-SHBG yabesifazana iyancipha, bakhuluma mayelana nokuthuthukiswa kwezifo. Ezimweni eziningi lokhu kungukuthi:
- i-nephrotic syndrome (ukuphazamiseka kwesistimu ye-excretory);
- amazinga okwanda kwama-androgens egazini - hyperadromia ;
- isifo sikashukela mellitus ;
- i-acromegaly;
- Isifo sikaCushing;
- ukwanda kwamazinga e-prolactin egazini;
- i-polycystic ovarian syndrome;
- i-cirrhosis yesibindi;
- imithi, ikakhulukazi: iDanazol, iSomatostatin, kanye nemithi equkethe i-androgens ne-glucocorticoids.
Ungalawula kanjani izinga le-SHBG?
Ukuze unqume izinga le-SHBG emzimbeni wesifazane, isampuli segazi senziwa. Lemibandela elandelayo kumele ibonwe:
Ukuhlaziywa kwenziwa ngesisu esingenalutho, ekuseni. - Amahora angu-72 ngaphambi kwenkambiso, kubalulekile ukukhansela ukudliwa kwazo zonke izidakamizwa ze-hormonal.
- Yeka ubulili.
Ngokuvamile umphumela wokuhlaziywa usuvele uwazi ngemva kosuku. Ngesikhathi esifanayo, ukucubungula kwayo kufanele kwenziwe kuphela udokotela. Ngakho-ke, umazi ukuthi lokhu kuyi-SHGG, futhi okwenziwe, owesifazane akufanele akhathazeke ngemva kokuthola umphumela wokuhlaziywa, futhi akukho mbuzo okufanele enze iziphetho ezizimele, kodwa ngokuqinisekile uzokuthola iseluleko kumjozi wezinkinga zokubeletha.