Esinye sezimbangela ezivame kakhulu zokungabikho komzimba yi- hyperandrogenism kubantu besifazane - isifo se-endocrine system. Lokhu kutholakala kuyatholakala kuma-20% wabesifazane.
I-Hyperandrogenism kubantu besifazane - kubangela
I-Hyperandrogenia kubantu besifazane iwumphumela wezifo ze-endocrine, kanye nezicubu zesimiso se-endocrine - i-pituitary (njengengxenye yesimiso se-hypothalamic-pituitary), i-thymus, i-thyroid, i-pancreas, i-adrenals ne-gonads). Futhi, imbangela yenyuka yokwanda kwamahomoni wesilisa - androgens - yi-adrenogenital syndrome. Inani elikhulu lamahomoni wesilisa liguqulwa libe yi-glucocorticoids ngaphansi kwesenzo se-enzyme ekhethekile, okukhiqizwa okuyinto eyenziwe ihlelwe ngokwezakhi zofuzo. Esinye isizathu se-hyperandrogenism kubantu besifazane kubizwa ngokuthi izicubu ezidalwa yi-adrenal tumors. Ukwanda kwamangqamuzana akhiqiza i-androgens kakhulu kwandisa inani lama-hormone wesilisa. Ukwandisa ukukhiqizwa kwama-hormone ocansini wesilisa nakho kungabangelwa ukuzwela kwesikhumba ku-sex hormone - testosterone.
I-Hyperandrogenia yabesifazane - izimpawu
I-Hyperandrogenia yisimiso esibonakalayo emitholampilo nge-acne, seborrhea, ne-hirsutismome ne-alopecia encike ekutheni i-alopecia. Kulesi simo, ukuhlolwa kwegazi kungabonisa ukuphakama noma izinga elijwayelekile le-androgens (ama-hormone wesilisa wesilisa). Izinguquko ze-Ovarian, izici ze-polycystic ovaries, ziphinde zitholwe. Isici esiyinhloko, futhi nesici se-syperrome ye-hyperandrogenism kubantu besifazane, esibangelwa ukwanda kwe-androgens, ukuphulwa komjikelezo wokuya esikhathini, kamuva ukungazalwa, imijikelezo yokugcoba. I-Hyperandrogenia emantombazaneni iphuza ukuqala kokuya esikhathini iminyaka eminingana.
I-Hyperandrogenism kwabesifazane ihambisana nokukhuluphala. Izinguquko esikhumbeni zihambisana nokubunjwa kwamacon (amnyama). Futhi, i-hyperandrogenia ibangela izinguquko ezingenakuguquka eziholela ekwakheni ama-cysts amancane nokwakhiwa kwe-capsule ezungeze ama-ovari. Ezimpawu zangaphandle zamazinga aphakeme a-androgens, ukuqhuma kwamagciwane, ukukhula ngokweqile kwezinwele emilenzeni, izandla. Izinguquko ezinkulu ema-ovari zingavimbela ukuvuthwa kwamaqanda, i-polycystosis.
Hyperandrogenism nokukhulelwa
Ochwepheshe baqaphela i-hyperandrogenism ye-adrenal, i-ovarian kanye nemvelaphi exubile. I-Hyperandrogenia ye-ovarian genesis ibangelwa okuqukethwe okwandisiwe kwe-sex hormone - testosterone, eyenziwa ngama-ovaries. Izimbangela zalesi sifo yizifo ezihlukahlukene ze-ovari: izicubu, i-polycystosis. Kubuye kuvame ukutholakala emantombazaneni asebenza emidlalweni yamandla. Ngesikhathi sokukhulelwa, i-hyperandrogenia ye-ovarian genesis ayiyona ingozi ebusweni nokubeletha, futhi ayidingi ukwelashwa. I-hyperandrogenism engavamile, evame ukubeletha noma eyabangela ukungabi namanzyme amaningi ahlanganyela ekwakheni i-cortisol, iyingozi kulabo abahlela ukukhulelwa noma abakhulelwe.
I-Hyperandrogenia yabesifazane ngesikhathi sokukhulelwa ingaholela ezinkingeni eziyingozi kakade ekudaleni kokubeletha, njengokuphuma okungapheli kwe-amniotic fluid nokusebenza komsebenzi obuthakathaka.