Wake wacabanga ukuthi kungani izidakamizwa ezinomumo ofanayo zivame ukuba nezindleko ezahlukene? Imodium ethandwa kakhulu iyabiza kakhulu kuneLoperamide, futhi ngemva kwakho konke lokhu okudinga izidakamizwa ngokufanayo, banomuthi owodwa osebenzayo. Izinkomba zokusetshenziswa kweLoperamide zizofana, futhi intengo yayo iyokumangaza ngokumangalisayo. Kuyini ukudoba?
Izici zeLoperamide Hydrolochromide
Ekubunjweni kwe-Imodium neLoperamide, ingxenye eyodwa kuphela yiLoperamide hydrochloride, izinkomba zokusetshenziswa zilandelayo:
- isifo sohudo ;
- isifo sohudo esingapheli;
- ukujwayelekile komzimba wamathumbu ngemuva kokuhlinzwa.
Izinkomba ezinjalo zeLoperamide zibangelwa ukuthi i-substance isifo esicindezelayo emisipha ebusayo yamathumbu futhi ngenxa yalokhu ukugcinwa kwesitokisi kwenzeka. I-Loperamide ibhekisela kuma-opioid amalungiselelo futhi isuka ku-piperidine. Ivimbela isenzo se-receptors yamathumbu asuke azwela ama-opiates futhi ngaleyo ndlela enza ukuba i-sphincter ivumelane, futhi imisebenzi yemoto iqhwa. Ekuqaleni, lesi sidakamizwa sasetshenziselwa ukwelapha i-gastroenteritis nezinhlobo ezihlukahlukene zokuvuvukala kwamathumbu, namanje isetshenziselwa ukulwa nesifo sohudo.
ULoperamide watholwa ososayensi baseBelgium ngo-1969 futhi kusukela ngaleso sikhathi kuye kwagqugquzelwa ngamandla emakethe ngaphansi kwegama elithi Imodium. Ngokufanayo, emazweni amaningi, ukufaniswa kwezidakamizwa zesidakamizwa esinokubunjwa okufanayo kukhishwe. Ekhaya laseLoperamida-Akri ngokuphelele izibonakaliso ezifanayo zokufaka isicelo. Kodwa ezinye zezidakamizwa zihlukile, okungukuthi - izinga lokuhlanzwa kwezinto ezisebenzayo, izinga lokulawula ekukhiqizeni kanye nokutholakala kwezifundo ezintsha emkhiqizo. Lokhu kunengqondo, ngoba ukukhiqizwa okungaphezulu, imali engaphezulu engayinika leyo mibuzo.
Ngokwesibonelo, ngawo-1990, uJohnson noJohnson, owayengumgqugquzeli we-Imodium, baxoshe lesi sidakamizwa emakethe ngenxa yokufa eziningana ePakistan. Ngemva kokusetshenziswa kwe-Imodium, izingane ezingu-19 zahlupheka. Ucwaningo oluqaphile lwe-loperamide kulokhu alupheli futhi le remedy yavuselelwa. Iqiniso liwukuthi ezinganeni futhi, ikakhulukazi, izinsana, i-piperidine kanye neziqhamo zalo ziholela ekugxileni kwemisipha yamathumbu kuze kube yilapho sekukhubazekile. Njengomthetho, umphumela onjalo ubonakala ezinganeni ezineminyaka engaphansi kwengu-2 ubudala, esikhathini esidala ukuphulwa okunjalo okwenzeki. Futhi, noma kunjalo, ukusebenzisa izidakamizwa, kuhlanganise loperamide, emazweni amaningi kuvunyelwe kuphela izingane ezingaphezu kweminyaka engu-6 ubudala, nase-Australia, izingane ezingaphezu kweminyaka engu-12 ubudala.
Isilinganiso nokuphathwa kweLoperamide
Ukuze ukwelashwa kwesifo sohudo esiphuthumayo, abantu abadala banikezwa umthamo wokuqala weLoperamide ngesamba esingu 4 mg, okuhambisana namaphilisi angu-2 omuthi. Esikhathini esizayo, thatha u-2 mg wemithi emva kwesitokisi ngasinye, uma iqhubeka ibe mnene, i-liquid. Uma kwenzeka ukuthi isitoli sijwayelekile, noma isiguli sinokuqothulwa , ukusetshenziswa kwamaphilisi e-Loperamide kufanele kukhishwe.
Ukuze ukwelashwa kwesifo sohudo esingapheli, abantu abadala baqokelwe u-2 mg wesidakamizwa izikhathi ezingu-1-2 ngosuku kuze kube yilapho isimo sigxilile.
Izingane ezingaphezu kweminyaka engu-6 zikhethwe ngabanye futhi zisekelwe esisiswini somzimba wengane. Ukwelapha
Umthamo wansuku zonke weLoperamide kubantu abadala u-16 mg, kubantwana abangu-6-8 mg.
Lapho ukwelashwa okuthiwa "isifo sohudo," isifo sohudo sokugula nesifo sofuba, lesi sidakamizwa senziwa ngokwe-scheme efana nokwelashwa kwesifo sohudo.
Ngokunakekelwa, i-Loperamide ilawulwa ngokuphulwa kwesibindi nezinso. Isidakamizwa siyaphikisana:
- ukhulelwe;
- omama abahlengikazi;
- izingane kuze kube yiminyaka engu-6.