I-OH-progesterone noma i-17-OH progesterone ayiyona i-hormone, nakuba ukuqala kokuqala kwegama kungukuthi. Amanye amagama awo angu-17-OH, i-17-OPG, i-17-alpha-hydroxyprogesterone. Kodwa kungakhathaliseki ukuthi kubizwa kanjani, itholakala ngenxa yesimetabolism yama-hormone e-steroid eyimfihlo yama-ovari kanye ne-cortex e-adrenal.
I-17-OH progesterone ingumkhiqizo obalulekile owuqedile, okuvela kuwo ama-hormone. Izinga elincishisiwe noma eliphakeme lalezi zinto akumele lidale ukukhathazeka ngesikhathi sokukhulelwa. Nokho, kwezinye izikhathi, lokhu kufanele kuxwayise.
Uma i-pro-protheone engu-17-OH iyancipha
Uma izinga le-17-OH progesterone liphansi ngesikhathi sokukhulelwa, alithwali ingane. Phakathi nalesi sikhathi, ukuhlolwa kwegazi akuhlinzeki ngolwazi oluwusizo kudokotela nesiguli. Kubaluleke kakhulu ukucacisa izinga le-progesterone emntwaneni ngemuva kokuzalwa.
Ngokuvamile, ukuhlaziywa kwe-17-OH progesterone kuthathwa ngosuku lwesine-5 lwenyanga yokuya esikhathini. Yenza lokhu kungakapheli amahora angu-8 ngemuva kwesidlo sokugcina. Kunezimo ezithile zokuhlushwa kwalesi sici, kuye ngokuthi isigaba somjikelezo nesikhathi salo wesifazane. Ekukhulelwe, kuvame ukukhula ku-17-OH progesterone.
Uma i-proxy-17-OH isinciphisa (asikhulumi ngesikhathi sokukhulelwa), lokhu kubonisa izinkinga eziningi emzimbeni, njenge:
- Isifo se-Addison (ukungakwazi ukuhlala okungapheli kwe-cortex ye-adrenal);
- ukuhlukunyezwa kwezitho zokuzala kubafana.
Uma owesifazane enesifo sokungasebenzi komzimba we-cortex eyingozi, lokhu kungabangela ukungabi nabantwana , nakuba ngokuvamile izimpawu zingabonakali futhi owesifazane usukhulelwe ngokukhulelwa futhi ebeletha.
Kodwa-ke, uma kukhona okungavamile ekukhiqizeni i-pro-prote-17-OH, thintana nodokotela. Kukhona wonke amathuba ongawasebenzisa, ngokusiza ukwelashwa okufika ngesikhathi, ukuvuselela izinga lezinto futhi ugweme imiphumela embi.