I-hemoglobin ene-glycated ingenye yezinkomba zezinto eziphilayo ezibonisa izinga lokushukela egazini isikhathi eside. Ukuhlaziywa kwe-hemoglobin eglycated kunendima ebalulekile ekuxilongweni kwesifo sikashukela mellitus, kanye nasekuqapheleni okuqhubekayo isimo sesiguli esitholakalayo.
Ukuhlaziywa kubonisa ngani i-hemoglobin glycated?
I-hemoglobin ene-glycated ikhona egazini lomuntu ngamunye, futhi inani layo linqunywa njengephesenti ye-hemoglobin ephelele egazini.
I-hemoglobin eglycated isakhiwe ngenxa ye-fusion ye-glucose ne-hemoglobin, lapho ama-enzyme awahlanganyeli khona. Ngenxa yalokho, kukhona inhlanganisela ephikisayo engaqali futhi ikhona kumaseli obomvu egazi (i-erythrocytes) yonke isikhathi sokuphila kwayo. Njengoba i-hemoglobin ene-glucose ayibopheli ngokushesha, futhi isikhathi sokuphila kwamaseli abomvu singaba izinsuku ezingu-120, lesi sichazamazwi asisho ukuthi isishukela samanje sisigazini, kodwa silinganiselwe isikhathi esingaphezu kwezinyanga ezintathu.
I-hemoglobin ene-glycated ephakeme futhi ephansi
Ngezinhloso zokuxilonga, lokhu kuhlaziywa kusetshenziselwa isifo sikashukela semithi yonke yezinhlobo nezimo zesandulela ngculazi. Njengoba ephakeme izinga lokushukela, i-hemoglobin eboshwe kakhulu, ngakho-ke i-hemoglobin ene-glycated iphakanyiswe ezigulini ezine-diabetes mellitus.
Ukujwayelekile kubhekwa ukuthi kuvela ku-4 kuya ku-6%, kanti i-hemoglobin ye-glycated kusuka ku-6.5 kuya ku-7.5% yisimo sesandulela ngculazi, amanani aphakeme akhombisa ukuthi kukhona khona isifo sikashukela esingenasiphelo. Ngaphezu kwalokho, ukungabi nensimbi kungaba yimbangela.
Kodwa-ke, kunezici eziningana zezifo, ngenxa yokuthi i-hemoglobin ene-glycated ingaba yanda noma iyancipha, futhi isithombe somtholampilo siphutha.
Inkomba inganyuswa nge:
- ukungabi nensimbi (kulokhu, ukutholakala kwe-anemia ye-iron, i-hemoglobin ephelele egazini iyancipha, ngakho-ke inani lenkinga liphakeme);
- uketshezi nge-salts yokuhola noma ukuphuza utshwala;
- ukwehluleka kwezinso ngenxa yokuqoqa egazini lemikhiqizo yokubola, engaxhunywanga emzimbeni;
- ipeni elikude.
I-hemoglobin ye-glycated eyancipha ingenzeka uma:
- ukuphuma kwegazi;
- i-hypoglycemia ende;
- i-hemolytic anemia (lapho isikhathi sokuphila samangqamuzana egazi obomvu kunciphisa);
- ngemva kokumpontshelwa igazi.
Ukuhlolwa kwegazi nge-hemoglobin eglycated
Ngokungafani novivinyo oluningi, ukunikela ngegazi ukuze i-hemoglobin ene-glycated ayikwazi ukuyenza esiswini esingenalutho. Njengoba lolu cwaningo lubonisa izinga lokushukela eliphakathi kwezinyanga ezintathu, izinkomba zamanje ezikulo azikwazi ukuphazamisa.
Futhi, izinga le-hemoglobin eli-glycated alithintekile noma lithonywe ukudla okuncane kakhulu kwezidakamizwa eziningi, amakhaza nezifo zokuphefumula, isimo somzwelo sesiguli. Izinkomba zingathinteka ekulahlekelweni kwegazi (kunikezwe ukukhubazeka komjikelezo wokuya esikhathini nokugaya kakhulu abesifazane) kanti abanye
Ngaphezu kwalokho, ukuhlanekezela izinkomba (kancane kancane) kungathatha izinsuku ezimbalwa ngaphambi kokuhlolwa kwamalungiselelo ensimbi, ukusetshenziswa kwenani elikhulu lokudla okunezinsimbi newayini elibomvu. Uma izidakamizwa zokwandisa izinga eliphelele le-hemoglobin zithathwa njalo, ngakho aziphambukisi isithombe somtholampilo.
Kumele kukhunjulwe ukuthi ucwaningo olwenziwe nge-glycated hemoglobin emitholampilo ehlukene (ukusebenzisa izindlela ezahlukene) lungabonisa imiphumela ehlukile. Ngakho-ke, uma ukuhlolwa kuqhutshwa njalo, ukuqapha isimo jikelele, kungcono ukusebenzisa izinsizakalo zelabhorethri eyodwa.