Amazinga aphakeme we-cholesterol egazini ayingozi empilweni. Kodwa ungabhekana nale nkinga ngokusebenzisa izidakamizwa ezikhethekile: izitembu nama-fibrate. Zithinta izinqubo ezihlukahlukene ze-biochemical ezenzeka hhayi kuphela ekhiqizweni kwe-cholesterol, kodwa futhi nasekuguqulweni kwayo emzimbeni womuntu.
Izitatimende zokunciphisa i-cholesterol
Izitatimende yizidakamizwa zanamuhla ezithandwayo ezinciphisa i-cholesterol egazini. Basiza ngempela masinyane, ngoba isimiso sabo sesenzo sisekelwe ekuvinjweni kwe-enzyme, esesibindi futhi inesibopho sokukhiqizwa kwe-cholesterol. Enye yezimiso ezivame kakhulu, eziphephile futhi eziphumelelayo yi-Simvastatin. Umthelela wokwelashwa waleso sidakamizwa uqala ezinsukwini ezingu-14 emva kokuqala kokwelashwa. Kodwa emva kokuqeda ukwelashwa, izinga le-cholesterol lizobuyela kancane kancane ezingeni layo langempela. I-Simvastatin cishe ayikho inqunquthela. Lawa amaphilisi angasetshenziswa njengendlela yokuvimbela iziguli ezine-artery disease noma isifo sikashukela esikuvimbela ukuthuthukiswa kwezinkinga ezihlukahlukene ze-cardiovascular.
Kwezidakamizwa ezinciphisa i-cholesterol egazini, kuhlanganisa i-Atorvastatin. Lezi amaphilisi ngokuvamile zichazwe kulabo abagulayo abangenayo isenzo esanele ngokwanele ekudleni kanye nezinye izinyathelo ezingezona zokwelapha. I-Atorvastatin inciphisa kakhulu ingozi:
- ukuthuthukiswa kwesifo sohlangothi kanye ne-angina pectoris;
- Ukufa kwesifo se-ischemic ;
- ukwenza umsebenzi we-revascularization.
Sebenzisa ukunciphisa ngokushesha i-cholesterol, kanye nokuvimbela ukuthuthukiswa kwesifo sokuqina kwesifo sofuba kanye ne-Pravastatin. Lezi amaphilisi ziyasebenza ngempela, kodwa ngaphambi nangesikhathi sokwelashwa, kunomthetho ukugcina ukudla okukhethekile okulwa ne-cholesterol. I-Atorvastatin ne-Pravastatin yizidakamizwa ze-statin ezinciphisa i-cholesterol egazini, elingenakuthathwa ngezifo zesifo samasipha, izifo ezihlukahlukene zesibindi (ikakhulukazi esigabeni esisebenzayo) nangesikhathi sokukhulelwa.
I-Fibrate yokunciphisa i-cholesterol
Izitatimende zithinta i-cholesterol encane kakhulu. Kuthiwani uma ubukhulu balo bukhulu ngokwanele? Yiziphi izidakamizwa ezinciphisa i-cholesterol egazini kulokhu? Ama-Fibrate azokusiza. Lezi amaphilisi ezithinta i-lipid metabolism. Imithi engcono kakhulu eyanciphisa i-cholesterol egazini ngisho nasezingeni eliphezulu kakhulu:
- Bezafibrate;
- I-Profrofibrate;
- Gemfibrozil;
- Fenofibrate.