Kuyaziwa ukuthi isikhathi sokuya esikhathini siwumphumela wemvelo wezinguquko ezihlobene nobudala obuhlobene nokuqedwa komsebenzi wokubeletha. Kodwa-ke, izifo zesimiso esivumelanako ngezinye izikhathi azigcini nje ngokubangela ukuhlukunyezwa kwesifazane, kodwa futhi kuthinta kakhulu izinga lempilo nomsebenzi womsebenzi. Inqubo yokulungiswa kwe-hormone, lezi zifo ezilandelayo zingase zivele:
- isimo sengqondo-ngokomzwelo;
- uhlelo lwe-vegetative nesifo senhliziyo;
- izifo zesistimu ye-genitourinary;
- ukwehlisa isifiso socansi.
Futhi lokhu akulona uhlu oluphelele lwazo zonke izikhathi ezingathandeki ezihlotshaniswa nokunciphisa inani le-estrogen elikhiqizwa emzimbeni wesifazane ngokuya esikhathini.
I-Estrogens enekhono lokuya esikhathini
Ukuze unciphise ukubonakaliswa kwezibonakaliso zezici ekunqumeni kokuya esikhathini, izidakamizwa ezine-estrogen zivame ukusetshenziswa. Le okuthiwa i-hormone replacement therapy isetshenziselwa ukuvimbela nokulungisa izinkinga ezihlobene nokudonsa ezingeni lika-estrogen esikhathini sokumisa esikhathini. Amalungiselelo asetshenziselwa i-HRT ahlukaniswe ngamaqembu amabili ngokusho kwawo:
- Kuphela kokuqukethwe kwe-estrogen. Ngokuvamile kuvame ukuqokwa ngemva kokuhlinzwa (ukususwa kwesibeletho).
- Iqukethe i- estrogen ne-progesterone . I-progesterone isetshenziselwa ukuvikela i-endometrium.
Kumele kuqashelwe ukuthi ngezidakamizwa ezinama-estrogens kufanele ziphathwe ngokucophelela okukhulu, ngoba zinokuphikisana okuningana. Akuvunyelwe ukusebenzisa izidakamizwa ze-estrogenic zabafazi besilisa abanesifo esinjalo:
- umdlavuza webele, i-endometrium, isisu, i-melanoma;
- izifo zesibindi, i-biliary tract, inhliziyo, ukuphazamiseka kwegazi (ukushaya kwenhliziyo, isifo sohlangothi, thrombophlebitis, njll);
- ukuphuma kwezimvelaphi ezingaziwa.
Futhi, ukulungiswa nge-estrogens akukhuthazwa abesifazane besifazane abane- endometriosis , i-myomas ye-uterine, abesifazane abane-high blood pressure.
Ngisho noma kungekho ukuphikisana okuphawulekayo kokusetshenziswa kwama-estrogen amalungiselelo ekunqophiseni isikhathi, i-HRT kufanele inqunywe ngaphansi kokuqondiswa kukadokotela, ngokucabangela izici zomuntu ngamunye nokubonakaliswa kwezimpawu. Uma uthatha le mithi, ukuhlolwa okuvamile kwe-pelvic kuyadingeka. Iziguli ezasebenzisa izidakamizwa ezingenayo i-progesterone ngaphezu kokuhlolwa okuvamile kufanele zinikezwe i-biopsy yomdlavuza noma izinguquko ezinqandekile ku-endometrium.